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ucsdhealthsciences:

Finding Keys to Glioblastoma Therapeutic Resistance
Researchers at the University of California, San Diego School of Medicine have found one of the keys to why certain glioblastomas – the primary form of a deadly brain cancer – are resistant to drug therapy. The answer lies not in the DNA sequence of the tumor, but in its epigenetic signature. These findings have been published online as a priority report in the journal Oncotarget.
“There is a growing interest to guide cancer therapy by sequencing the DNA of the cancer cell,” said Clark Chen, MD, PhD, vice-chairman of Research and Academic Development, UC San Diego Division of Neurosurgery and the principal investigator of the study. “Our study demonstrates that the sensitivity of glioblastoma to a drug is influenced not only by the content of its DNA sequences, but also by how the DNA sequences are organized and interpreted by the cell.”
The team of scientists, led by Chen, used a method called comparative gene signature analysis to study the genetic profiles of tumor specimens collected from approximately 900 glioblastoma patients. The method allows investigators to discriminate whether specific cellular processes are “turned on” or “turned off” in glioblastomas. “Our study showed that not all glioblastomas are the same. We were able to classify glioblastomas based on the type of cellular processes that the cancer cells used to drive tumor growth,” said Jie Li, PhD, senior postdoctoral researcher in the Center for Theoretical and Applied Neuro-Oncology at UC San Diego and co-first author of the paper.
One of these cellular processes involves Epidermal Growth Factor Receptor (EGFR). The study revealed that EGFR signaling is suppressed in a subset of glioblastomas. Importantly, this suppression is not the result of altered DNA sequences or mutations. Instead, EGFR is turned off as a result of how the DNA encoding the EGFR gene is organized in the cancer cell. This form of regulation is termed “epigenetic.” Because EGFR is turned off in these glioblastomas, they become insensitive to drugs designed to inhibit EGFR signaling.
“Our research suggests that the selection of appropriate therapies for our brain tumor patients will require a meaningful synthesis of genetic and epigenetic information derived from the cancer cell,” said co-first author Zachary J. Taich.

ucsdhealthsciences:

Finding Keys to Glioblastoma Therapeutic Resistance

Researchers at the University of California, San Diego School of Medicine have found one of the keys to why certain glioblastomas – the primary form of a deadly brain cancer – are resistant to drug therapy. The answer lies not in the DNA sequence of the tumor, but in its epigenetic signature. These findings have been published online as a priority report in the journal Oncotarget.

“There is a growing interest to guide cancer therapy by sequencing the DNA of the cancer cell,” said Clark Chen, MD, PhD, vice-chairman of Research and Academic Development, UC San Diego Division of Neurosurgery and the principal investigator of the study. “Our study demonstrates that the sensitivity of glioblastoma to a drug is influenced not only by the content of its DNA sequences, but also by how the DNA sequences are organized and interpreted by the cell.”

The team of scientists, led by Chen, used a method called comparative gene signature analysis to study the genetic profiles of tumor specimens collected from approximately 900 glioblastoma patients. The method allows investigators to discriminate whether specific cellular processes are “turned on” or “turned off” in glioblastomas. “Our study showed that not all glioblastomas are the same. We were able to classify glioblastomas based on the type of cellular processes that the cancer cells used to drive tumor growth,” said Jie Li, PhD, senior postdoctoral researcher in the Center for Theoretical and Applied Neuro-Oncology at UC San Diego and co-first author of the paper.

One of these cellular processes involves Epidermal Growth Factor Receptor (EGFR). The study revealed that EGFR signaling is suppressed in a subset of glioblastomas. Importantly, this suppression is not the result of altered DNA sequences or mutations. Instead, EGFR is turned off as a result of how the DNA encoding the EGFR gene is organized in the cancer cell. This form of regulation is termed “epigenetic.” Because EGFR is turned off in these glioblastomas, they become insensitive to drugs designed to inhibit EGFR signaling.

“Our research suggests that the selection of appropriate therapies for our brain tumor patients will require a meaningful synthesis of genetic and epigenetic information derived from the cancer cell,” said co-first author Zachary J. Taich.

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onlylolgifs:

IXION Windowless Jet Concept

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designcloud:

The Abyss Table by Duffy London

This mesmerising table was first conceived by Christopher Duffy — and ultimately refined by the team at Duffy London — to represent a 3D geological map of an ocean floor. The Abyss Table makes use of contour lines, which are often used to denote topography in terrain maps, to render an island chain and ocean abyss.

Contour lines can be thought of as workaround for the 2D limitations of paper maps, but Duffy instead relished these simplifications which have become iconic imagery for the field of cartography. He incorporates layers of wood to represent the land, and panes of glass for the water, in order to produce a 3 dimensional geographical model.

(via Homeli)

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lincecumesque:

The most hardcore handshake of all time. 

lincecumesque:

The most hardcore handshake of all time. 

(via onlylolgifs)

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ancientart:

Here is one of the earliest known reliefs to commemorate the legitimate marriages of former Roman slaves. 
The Funerary Stele of Aurelius Hermia and his wife Aurelia Philematium is from the tomb on Via Nomentana, and dates to ca. 80 BCE.
The British Museum provides the following prose translation of the funerary stele:
"Aurelius Hermia, freedman of Lucius, butcher by trade from the Viminal Hill. My partner who departed this life before me was pure of body and loving of spirit. She was the only one for me, and lived her life faithful to her faithful husband, with equal devotion. She never failed in her duties through self-interest or greed. Aurelia, freedwoman of Lucius.
Aurelia Philematio, freedwoman of Lucius. In life, I was given the name Aurelia Philematium (little Kiss) and led a chaste, modest and sheltered life, faithful to my husband. Aurelius, my husband, whom I now sadly miss, was a fellow freedman. He was, in fact, much more to me than even a parent. He took me into his care at the age of seven. Now at the age of forty, I fall into the hands of death. He flourished in the eyes of others due to my constant and close support.”
Courtesy of & currently located at The British Museum, London, 1867,0508.55. Photo taken by Sebastià Giralt.

proving that, even generations ago, men could be as skeevy as woody allen and/or René Angélil.

ancientart:

Here is one of the earliest known reliefs to commemorate the legitimate marriages of former Roman slaves. 

The Funerary Stele of Aurelius Hermia and his wife Aurelia Philematium is from the tomb on Via Nomentana, and dates to ca. 80 BCE.

The British Museum provides the following prose translation of the funerary stele:

"Aurelius Hermia, freedman of Lucius, butcher by trade from the Viminal Hill. My partner who departed this life before me was pure of body and loving of spirit. She was the only one for me, and lived her life faithful to her faithful husband, with equal devotion. She never failed in her duties through self-interest or greed. Aurelia, freedwoman of Lucius.

Aurelia Philematio, freedwoman of Lucius. In life, I was given the name Aurelia Philematium (little Kiss) and led a chaste, modest and sheltered life, faithful to my husband. Aurelius, my husband, whom I now sadly miss, was a fellow freedman. He was, in fact, much more to me than even a parent. He took me into his care at the age of seven. Now at the age of forty, I fall into the hands of death. He flourished in the eyes of others due to my constant and close support.”

Courtesy of & currently located at The British Museum, London, 1867,0508.55. Photo taken by Sebastià Giralt.

proving that, even generations ago, men could be as skeevy as woody allen and/or René Angélil.

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aberrantbeauty:

Monica Lee’s Graphite Drawings

aberrantbeauty:

Monica Lee’s Graphite Drawings

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(Source: sighsomemore, via onlylolgifs)

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tumblropenarts:

Artist Name: Joe Papagoda
Tumblr: http://woyo.tumblr.com/
 Interested in this painting? Contact the artist

tumblropenarts:

Artist Name: Joe Papagoda

Tumblr: http://woyo.tumblr.com/

 Interested in this painting? Contact the artist

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